Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 50: Posters - Cell Adhesion
BP 50.6: Poster
Mittwoch, 9. März 2016, 17:00–19:00, Poster C
Microbial adhesion on nanorough titanium: Insight into the nanostructure of the microbe-material-interface — •Claudia Lüdecke-Beyer1,3, Martin Roth2,3, Jörg Bossert1,3, and Klaus D. Jandt1,3 — 1Otto Schott Institute of Materials Research, Chair of Materials Science, Friedrich Schiller University, Jena, Germany — 2Leibniz Institute for Natural Product Research and Infection Biology, Bio Pilot Plant, Hans Knöll Institute, Jena, Germany — 3Jena School for Microbial Communication (JSMC), Excellence Graduate School, Friedrich Schiller University, Jena, Germany
Implant-associated infections are primarily initiated by the adhesion of microorganisms on the implants` surfaces. Recently, materials with surface roughnesses in the nanometer range gained interest to reduce microbial adhesion, however, the mechanisms remained so far unclear. The aim of this study was to explore the unknown nanostructure of the microbe-titanium-interface to gain understanding of the physical mechanism of microbial adhesion as a function of nanoroughness. Microbial adhesion was investigated using physical vapor deposited titanium thin films as nanorough 2D model surfaces. We found evidence that with decreasing titanium surface peak density and decreasing specific titanium surface area the surface coverage with microbes was reduced. Investigating the structure of the microbe-material-interface indicated that the initial adhesion of the microbes is controlled by the number of nano contact points between the microbial cell and the material`s surface. These findings support the development of new antibiotic-free strategies to prevent implant-associated infections.