Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 50: Posters - Cell Adhesion
BP 50.7: Poster
Mittwoch, 9. März 2016, 17:00–19:00, Poster C
Nano contact points control initial microbial adhesion on biomaterials surfaces — •Carolin Dewald1,2,3, Claudia Lüdecke-Beyer1,3, Martin Roth2,3, Jörg Bossert1,3, and Klaus D. Jandt1,3 — 1Otto Schott Institute of Materials Research, FSU Jena, Germany — 2Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany — 3Jena School for Microbial Communication, FSU Jena, Germany
New antibiotic-free strategies are needed for prevention of biomaterials-associated infections. Our preliminary results indicated that microbial adhesion is controlled by the nano contact points between the microbes and the material`s surface. The aim of this study was to use nanoparticles (NPs) for physically structuring materials` surfaces to modulate the number of possible contact points between the microbes and the nanostructured surfaces. 15 nm gold NPs were immobilized in different concentrations to gold surfaces. Microbial adhesion on these surfaces as well as the nanostructure of the microbe-material-interface was investigated to gain understanding of the physical mechanisms of microbial adhesion as function of the material`s nanostructure. With decreasing NP density, microbial adhesion was statistically significantly reduced. High resolution SEM revealed that the NPs controlled the initial contact between the microbial cells and the material`s surface. We assume that the total adhesion strength is correlated with the NP density i. e. the contact point density. Our new findings suggest that adjusting the nanostructure of biomaterials` surfaces might be a promising antibiotic-free approach for controlling microbial adhesion.