Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 53: Posters - Statistical Physics of Biological Systems

BP 53.7: Poster

Mittwoch, 9. März 2016, 17:00–19:00, Poster C

Geometric hindrance in multi-species transport on microtubules — •Patrick Wilke, Emanuel Reithmann, and Erwin Frey — Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität, Munich, Germany

Intracellular transport on microtubules is performed by molecular motors which have for a long time been thought to move exclusively longitudinally to the axis of the cylindrically shaped biopolymer. Recent experimental studies have revealed that, opposed to this standard hypothesis, motion on spiraling paths is observed for many kinesin such as kinesin-2 [1] and 8 [2]. Here, we study collective transport of multiple particle species which move along different, periodically intersecting spiraling paths on a cylinder. Based on a lattice gas description we find that these intersections provoke correlations in the exclusion process which significantly influence the particle flux. Opposed to classical transport models, our system is characterized by a vanishing particle current at densities far below full occupation. To account for such effects, we develop an analytic framework which allows us to compute the current reduction due to geometric hindrance and the underlying correlations. Surprisingly, the stationary particle-density profile exhibits spatially oscillating patterns which are unfeasible in classical single-species ore one-dimensional models.

[1] M. Brunnbauer et al. Molecular cell 46.2 (2012): 147-158.

[2] V. Bormuth et al. Biophysical journal 103.1 (2012): L4-L6.