Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 59: DNA, RNA and Related Enzymes

BP 59.1: Hauptvortrag

Donnerstag, 10. März 2016, 09:30–10:00, H45

RNA-based gene circuits in vitro and in vivo — •Friedrich Simmel — TU München, Garching, Germany

The sequence-progammability of nucleic acids not only allows the design of complex supramolecular structures, but also the realization of dynamically switchable molecular devices. In particular RNA-based switches can be utilized as "rationally designed" genetic regulators, and can thus be used for the realization of artificial gene regulatory circuits. In this talk, a variety of examples of dynamical systems will be described, which can be implemented with such components - either using in vitro gene transcription, cell-free gene expression, or even in vivo.