Regensburg 2016 – wissenschaftliches Programm

Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe

BP: Fachverband Biologische Physik

BP 61: Anomalous Diffusion in Complex Environments (Focus Session)

BP 61.3: Vortrag

Donnerstag, 10. März 2016, 12:00–12:15, H45

Impact of detachment frequency on transport dynamics of cytoskeletal motor proteins — •Anne E Hafner, M Reza Shaebani, Ludger Santen, and Heiko Rieger — Department of Theoretical Physics, Saarland University, Saarbrücken, Germany

Cytoskeletal motor proteins are involved in key intracellular transport processes which are vital for maintaining appropriate cellular function. The motors exhibit distinct states of motility: active motion along filaments, and inactive state in which the motor detaches from the filament and remains effectively stationary by performing passive diffusion in the vicinity of the detachment point due to cytoplasmic crowding until it attaches again to the cytoskeleton. The rates of transitions between motion and pause states are considerably affected by changes in environmental conditions which influences the efficiency of cargo delivery to specific targets. By considering the motion of molecular motor on a single filament as well as a dynamic filamentous network, we present an analytical model for the dynamics of self-propelled particles which undergo frequent pause phases, and validate the theoretical predictions by performing extensive Monte Carlo simulations. The transition rates between the two states drastically change the dynamics: multiple transitions between different types of anomalous diffusive dynamics may occur and the crossover time to the asymptotic diffusive or ballistic motion varies by several orders of magnitude. We map out the phase diagrams in the space of transition rates, and address the role of initial conditions of motion on the resulting dynamics.