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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 44: Poster: Biomaterials and Biopolymers
CPP 44.5: Poster
Wednesday, March 9, 2016, 18:15–21:00, Poster B2
Three-dimensional microstructures on flexible substrates fabricated by two-photon polymerization for use as cell substrates and for wetting experiments — •Cristina Plamadeala1, Johannes Heitz1, Jaroslaw Jacak1, Gerda Buchberger2, Werner Baumgartner2, Birte Magnus3, and Rainer Marksteiner3 — 1Institute of Applied Physics, Johannes Kepler University Linz, Austria — 2Innovacell Biotechnologie AG, Innsbruck, Austria — 3Institute of Biomedical Mechatronics, Johannes Kepler University Linz, Austria
Polymer microstructures with various geometries are written onto a flexible substrate by the technique of two-photon polymerization by a Ti-sapphire femtosecond-laser, which is focused into a liquid acrylate based resin containing a photo-initiator. The microstructures are employed either as three-dimensional tissue scaffold onto which adherent cells can be seeded or are used as topological substrates for wetting experiments. Due to confinement to the microstructures and/or mechanical interaction with the scaffold, the cells are stimulated to grow three-dimensionally and to produce calcium binding proteins. There are some similarities in the way the microstructures are filled by cells and by water in wetting tests. Beyond the use of cell scaffolds, the structures may therefore have other potential applications in the field of microfluidics due to their good wettability and water sustainment.