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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 44: Poster: Biomaterials and Biopolymers

CPP 44.8: Poster

Mittwoch, 9. März 2016, 18:15–21:00, Poster B2

Tethered Polymers In Shear — •Richard Schwarzl and Roland Netz — Freie Universitaet Berlin, Fachbereich Physik, 14195 Berlin, Germany

We employ Brownian dynamics simulation including hydrodynamic interactions to model the dynamic properties of a polymer under shear flow conditions near a no-slip boundary. Our motivation is the von Willebrand factor, a large glycoprotein in blood. It is a crucial component in regulation of hemostasis. The conformational state of the large multimer determines vWFs ability to bind to other biological components such as collagen or bloodplatelets. Our focus is to build a bridge between single molecule pulling experiments and unfolding of vWF under shear.