Regensburg 2016 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 47: Poster: Interfaces and Thin Films

CPP 47.3: Poster

Mittwoch, 9. März 2016, 18:15–21:00, Poster B2

Molecular dynamics of itraconazole confined in thin supported layers — •Emmanuel Urandu Mapesa¹, Magdalena Tarnacka², Ewa Kamińska², Wilhem Kossack¹, Martin Tress¹, Wycliffe Kipnusu¹, Kamil Kamiński², and Friedrich Kremer¹ — ¹Institute for Experimental Physics I, University of Leipzig, Linnestr. 5, 04103, Leipzig, Germany. — ²Institute of Physics, University of Silesia, ul. Uniwersytecka 4, 40-007 Katowice, Poland.

Broadband Dielectric Spectroscopy (BDS) is used to study the molecular dynamics of thin layers of itraconazole - an active pharmaceutics ingredient with rod-like structure and whose Differential Scanning Calorimetry (DSC) scans reveal liquid crystalline-like phase transitions. It is found that (i) the structural relaxation process remains bulk like, within the limits of experimental accuracy, in its mean relaxation rate, while (ii) its shape is governed by two competing events: interfacial interactions, and crystalline ordering. Additionally, (iii) the dynamics of the delta-relaxation - assigned to the flip-flop rotation of the molecule about its short axis - deviates from bulk behaviour as the glass transition is approached for the confined material. These observations are rationalized within the framework of molecular dynamics as currently understood.