Regensburg 2016 – scientific programme
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 50: Wetting, Nano- and Microfluidics I (joint session CPP/DY, organized by CPP)
CPP 50.10: Talk
Thursday, March 10, 2016, 12:15–12:30, H42
Compact nanosensors probe microdroplets — •Julian Schütt1, Felix Zörgiebel1,2, Bergoi Ibarlucea1,2, Sebastian Pregl1,2, Daijiro Nozaki1, Walter Weber2,3, Thomas Mikolajick2,3,4, Larysa Baraban1,2, and Gianaurelio Cuniberti1,2 — 1Max Bergmann Center of Biomaterials and Institute for Materials Science, Dresden University of Technology, Budapesterstrasse 27, 01069 Dresden, Germany — 2Center for Advancing Electronics Dresden, 01062 Dresden, Germany — 3Namlab GmbH, Nöthnitzerstraße 64, 01187 Dresden, Germany — 4Institute for Semiconductors and Microsystems, TU Dresden, 01062 Dresden
Smart combination of nanosensors and droplets based reactors represents a powerful tool for monitoring and high throughput analysis of the kinetics of biological and chemical reactions, staying miniaturized, highly sensitive and optically label-free. Here we present a first demonstration of droplets microfluidics with the compact silicon nanowire field effect transistor (SiNW FET) on a single chip for in flow electrical detection of aqueous reactor-drops. Apart from detection events, we chemically probe the content of numerous droplets in a row as independent events (up to ten thousands), and resolve the pH values and ionic strength of the solution, resulted in a change of a source-drain current through the nanowires. Optic-less and noninvasive measurements of these parameters in aqueous droplets have a great impact on the area of biodetection and bioanalytics as a high throughput screening tool for pathogens, drug assays, and evaluation of the enzymatic activities.