Regensburg 2016 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 52: Focus: Two Dimensional Functional Materials I
CPP 52.9: Vortrag
Donnerstag, 10. März 2016, 12:15–12:30, H51
Quantitative SFM-Imaging of Graphene Functionalization: Toward Well-Defined Wrappings for Multivalent Virus Interactions — •Mohammad Fardin Gholami1, Daniel Lauster2, Kai Ludwig3, Julian Storm2, Benjamin Ziem3, Nikolai Severin1, Christoph Böttcher3, Jürgen P. Rabe1, Andreas Herrmann2, Rainer Haag3, and Mohsen Adeli3 — 1Institut für Physik & IRIS Adlershof, Humboldt-Universität zu Berlin — 2Institut für Biologie, Humboldt-Universität zu Berlin — 3Institut für Chemie und Biochemie, Freie Universität Berlin
Multivalency is widely used by nature to control biological interactions. Therefore, we also considered it for the design of a new generation of anti-viral drugs. Two-dimensional materials are promising carriers for multivalency. Graphene, in particular, is very robust yet chemically rather inert and therefore it is difficult to control the density distribution of its functionalization. We employed Scanning Force Microscopy (SFM) in quantitative imaging mode to investigate the functionalization of thermally reduced graphene oxide sheets and further used the sheets for the inhibition of the vesicular stomatitis virus (VSV) as a model virus. The functionalization of the sheets was carried out using a [2+1] nitrene cycloaddition reaction at ambient conditions. SFM imaging reveals a high density and homogenous distribution of the functionalization, depending on reaction conditions. Moreover, it allows to gain insight into the interaction of the multivalently functionalized sheets with VSV depending on the type and density of the functionalization.