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DS: Fachverband Dünne Schichten
DS 28: Thin Film Applications
DS 28.8: Vortrag
Mittwoch, 9. März 2016, 11:45–12:00, H8
Creation of various nanoporous surfaces for physically induced osteogenic stem cell differentiation — •Martin Gottschalk1, Matthias Schürmann2, Peter Heimann2, Barbara Kaltschmidt2, Christian Kaltschmidt2, and Andreas Hütten1 — 1Department of Physics, Center for Spinelectronic Materials and Devices, University of Bielefeld, D-33615, Germany — 22Department of Cell Biology, Faculty of Biology, University of Bielefeld, D-33615, Germany
The engraftment of orthopedic implants into bone tissue is mainly achieved by stem cells, which are differentiated into osteoblasts in the vicinity of the bone-implant-interface. It is known, that various surface topographies on the nanoscale are able to promote the differentiation process [2]. Thus, a physically induced differentiation by the topography of a titanium covered surface presents an interesting and promising alternative for future clinical use. It is known that anisotropically distributed 30 nm pores in a titanium coated polycarbonate membrane lead to cell differentiation [1]. The main approach is to generate a well-defined nanoporous surface in the pore-size-range of 30 nm by other approaches, like e-beam-lithography plus sputtering, to investigate further adjustments in the osteogenic cell differentiation. For a more precise analysis of the cell-pore-interaction in a TEM, a FIB-SEM-system is used to structure the needed pores into coated TEM grids.
References [1] M. Schürmann et al., Stem Cell Research 13, 98-110 (2014) [2] T. Sjöström et al., Nanomedicine 8, 89-104 (2013)