Regensburg 2016 – wissenschaftliches Programm
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MM: Fachverband Metall- und Materialphysik
MM 39: Biomaterials and Biopolymers I (joint session CPP/BP/MM)
MM 39.9: Vortrag
Mittwoch, 9. März 2016, 17:30–17:45, H40
Biomimetic Surface Templating of Silica Nanoparticles by Lysine-Leucine Peptide on Au Substrate — •Hao Lu1, Yeneneh Yimer2, Rüdiger Berger1, Mischa Bonn1, Jim Pfaendtner2, and Tobias Weidner1 — 1Max Planck Institute for Polymer Research, Mainz, Germany — 2Chemical Engineering University of Washington, Seattle, USA
Fabrication of silica thin films and architectures has led to many applications in electronic and optical devices, cosmetics, and catalysis; recently, bioinspired silica fabrication approaches have attracted great attention because of low production cost and mild, sustainable fabrication methods. We are the first to demonstrate that the biomimetic molecules can also exert control over silica mineralization when bounded to inorganic surfaces. We use amphiphilic helical peptides based on leucine and lysine side chains (LKa14) carrying cysteine terminal groups as linkers, providing stable covalent bond to gold surfaces. Using XPS, VSFG, and AFM, complemented by molecular dynamic simulation, we have investigated the silica mineralization process at the molecular level directly at the surface: In analogy to solution mineralization, the LKa14 peptides on Au tend to assemble into ordered lateral structures, maintain their solution state helical folding and are oriented upright on the surface. The LKa14 peptides nucleate silica nanoparticles at the surface, which then grow into larger, globular structures. This surface mineralization process serves as a well defined model system for lateral protein assembly and biomineralization and is of potential interest for the design of silica-based biomimetic coatings.