Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 16: Biotechnology and Bioengineering
BP 16.3: Vortrag
Dienstag, 21. März 2017, 12:15–12:30, HÜL 386
Self-assembled hybrid protein nanofibers as basis for novel biomaterials — •Christian Helbing1, Tanja Deckert-Gaudig2, Gang Wei3, Volker Deckert2, and Klaus D. Jandt1 — 1Chair of Materials Science, Department of Materials Science and Technology, Otto-Schott-Institute of Materials Research, Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Jena, Germany — 2Institute for Photonic Technology, Jena, Germany — 3Hybrid Materials Interfaces Group, Faculty of Production Engineering, University of Bremen, Bremen, Germany
Over the last years, the interest in materials consisting of biomolecules arranged in nanofibers increased. There is a special focus on plasma proteins for applications in nanofiber materials because of their high biocompatibility. An easy feasible strategy to create these nanofibers is the self-assembly mechanism of protein molecules. Here we test the hypothesis that novel self-assembled hybrid protein nanofibers (PNNF) can consist of two different proteins. In this work we present, for the first time, self-assembled plasma hybrid PNNF consisting of two different plasma proteins. Further, long-time CD-measurements provide information about the fiber formation dynamics. Especially, for the PNNF hybrid it confirmed interactions between both molecules. Additionally, the influence of the second protein on the properties of the novel hybrid PNNF is shown. We confirmed the existence of a novel PNNF hybrid by tip enhanced raman spectroscopy and immunolabeling. These results lay the foundation for a novel biomaterial based on these PNNF/PNNF hybrids.