Dresden 2017 – scientific programme

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BP: Fachverband Biologische Physik

BP 19: Posters - Computational Biophysics

BP 19.14: Poster

Tuesday, March 21, 2017, 14:00–16:00, P1A

In Silico Model for Vesicle Blebbing — •Sebastian Hillringhaus, Dmitry A. Fedosov, and Gerhard Gompper — Institute of Complex Systems, Forschungszentrum Juelich, Juelich, Germany

Experiments with vesicles that incorporate an action network show complex behavior and the formation of blebs when they are actively contracted through motor proteins [Loiseau et. al., Science Advances, 2016]. To understand the mechanics that lead to this observations, we employ a coarse-grained cell model which incorporates the membrane properties similar to the RBC-model [Turlier et. al., Nature Physics, 2016] and an elastic inner mesh to include the actin network. The model is formulated in the framework of the dissipative particle dynamics simulation method. To connect both the membrane and the actin network, we use the Two-Pathway Model [Pereverzev et. al., Biophysical Journal, 2005] which can model different behavior under tension. We perform various tests to evaluate the best parameters for this model to match the observed experimental data. We observe that the model of Catch-Slip bonds lead to the best fit with the experimental data.