Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 19: Posters - Computational Biophysics

BP 19.4: Poster

Dienstag, 21. März 2017, 14:00–16:00, P1A

Physical Analysis of One-Component Signaling in Bacteria — •Linda Martini and Ulrich Gerland — Physics of Complex Biosystems, Department of Physics, Technical University of Munich

Adaptation to changing environments is of vital importance to bacterial cells and is enabled by sophisticated signal transduction systems. While classical two-component signaling is well studied, the mechanisms of one-component systems, where a single protein implements both sensing and response regulation, are mostly uncharacterized.

One such one-component system is the membrane-integrated protein CadC, which is part of the pH-stress response system in E. Coli. As it directly binds to the genomic DNA to regulate transcription, it faces a target search problem the dynamics of which are still to be understood.

Using kinetic Monte Carlo simulations of a lattice model, we focus on a characterization of the coupled stochastic dynamics of the DNA and the proteins, and its dependence on the system parameters. Understanding the kinetics of membrane-localized proteins specifically binding to a dynamic DNA will be important to interpret corresponding in vitro experiments and more generally to understand the biophysics of one-component signal transduction.