Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 19: Posters - Computational Biophysics

BP 19.9: Poster

Dienstag, 21. März 2017, 14:00–16:00, P1A

Lateral trapping of DNA inside voltage gated nanopores — •Thomas Töws and Peter Reimann — Fakultät für Physik, Universität Bielefeld, 33615 Bielefeld, Germany

We consider a rigid cylinder, modelling a section of DNA, inside a solid state nanopore which is electrically gated by an all-around electrode integrated into the membrane. We study the interaction of DNA with the pore wall by means of potential energy landscapes. For this purpose we solve the fully 3D Poisson-Nernst-Planck and Stokes equations numerically and complement it by a 2D model and a 1D analytical calculation. We find that the DNA can be efficiently trapped parallel to the wall and off the symmetry axis of the pore by a proper choice of the gate voltage. Due to the hence induced confinement of accessible space lateral fluctuations of the DNA will be reduced. Furthermore we elucidate the dislike charge repulsion behaviour close to the wall which is necessary for such local minima of the potential energy.