Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 23: Posters - Statistical Physics of Biological Systems

BP 23.1: Poster

Dienstag, 21. März 2017, 14:00–16:00, P1A

Generic transport mechanisms for molecular traffic in cellular protrusions — •Isabella Krämer and Erwin Frey — Arnold Sommerfeld Center for Theoretical Physics, Ludwig-Maximilians-Universität, München, Deutschland

Transport of molecular motors along protein filaments in a half-closed geometry is a common feature of biologically relevant processes in cellular protrusions. Using a lattice-gas model we study how the interplay between active and diffusive transport and mass conservation leads to localised domain walls and tip-localisation of the motors. We identify a mechanism for task sharing between the active motors (maintaining a gradient) and the diffusive motion (transport to the tip), which ensures that energy consumption is low and motor exchange mostly happens at the tip. These features are attributed to strong nearest-neighbour correlations that lead to a substantial reduction of active currents, which we calculate analytically using an exact moment-identity.