Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 23: Posters - Statistical Physics of Biological Systems

BP 23.5: Poster

Dienstag, 21. März 2017, 14:00–16:00, P1A

Non-equilibrium dynamics of heterogeneous biological systems — •Federica Mura and Chase Broedersz — Department of Physics, Ludwig-Maximiliams-University Munich, Theresienstrasse 37, 80333 Munich, Germany

Recent experiments indicate that many biological systems, including the cytoplasm, actin-myosin networks, and chromosomal loci can be driven out of thermodynamic equilibrium. The active dynamics of these systems is governed by local stochastic forces resulting from enzymatic processes. To provide insight into the non-equilibrium dynamics of such systems, we propose a simple stochastic model of a d-dimensional bead-spring network subject to a heterogeneous distribution of random driving forces. By using a combination of numerical simulations and analytical results we investigate how this non-equilibrium setting affects the system's steady state dynamics. We discuss how detailed balance is broken in the stochastic dynamics of different degrees of freedom and use this to quantify the rate of entropy production. Ultimately, this model could help to establish a systematic and more general method to extract information from a trajectory analysis of the stochastic dynamics of biological systems.