Dresden 2017 – scientific programme

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BP: Fachverband Biologische Physik

BP 24: Posters - Protein Structure and Dynamics

BP 24.8: Poster

Tuesday, March 21, 2017, 14:00–16:00, P1A

Small-angle X-ray scattering study of aqueous Trypsin solutions and the influence of pressure on interaction potential — •Jan Latarius, Julian Schulze, Michael Paulus, Christian Sternemann, Jan Nysar, Göran Surmeier, and Metin Tolan — Fakultät Physik/DELTA, Technische Universität Dortmund, D-44221 Dortmund

Proteins as outmost important components of life show complex and non-intuitive behaviour regarding the interaction with themselves and each other under high pressure. Using the method of small-angle X-ray scattering we explore the properties of soluted Trypsin exposed to hydrostatic pressure and compare the findings to studies on aqueous solutions of Lysozyme and RNase. By altering the pressure in a range from 1 to 4000 bar with constant pH and adding co-solvents like TMAO and TMACl to differently concentrated protein solutions we hope to reveal the influence of co-solvents and pressure on the interaction potential.