Dresden 2017 – scientific programme

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BP: Fachverband Biologische Physik

BP 26: Posters - Cell Adhesion

BP 26.4: Poster

Tuesday, March 21, 2017, 14:00–16:00, P2-EG

Cell-cell adhesion in the optical stretcher - Methods for experimental and analytical force measurements — •Pablo Gottheil, Steffen Grosser, and Josef Käs — Germany, University of Leipzig, Faculty of Physics and Earth Sciences, Institute of Experimental Physics I, Soft Matter Physics Division

The optical stretcher is a dual-beam laser trap used to micromanipulate single cells in order to measure their viscoelastic properties. Here however, we use it to measure cell-cell adhesion forces, by stretching them apart from each other. The experimental way of approximating this force is to track the cells in the stretcher chamber and measure the speed in order to calculate the Stokes' law. Calculate the beampropagation and its diffraction by the cells can be used to analytically get the momenta in the whole cell chamber respectively before and after the diffraction. Comparing these two methods would give a nuanced view on the cell-cell adhesion forces.