Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 29: Posters - Multi-Cellular Systems
BP 29.1: Poster
Dienstag, 21. März 2017, 14:00–16:00, P2-EG
Stress-Strain Relation in Reconstituted Tissue — •Simone Gehrer1, Damir Vurnek1, Sara Kaliman1, Maryam Aliee1, Diana Dudziak2, Bernd Hoffmann3, Rudolf Merkel3, and Ana-Sunčana Smith1,4 — 1Puls Group, Institute for theoretical Physics, FAU Erlangen — 2University Clinic Erlangen — 3ICS-7:Biomechanics, Forschunszentrum Jülich — 4Division of Physical Chemistry, IRB Zagreb
Epithelial cells form active two-dimensional sheets that are involved in variety of functions like morphogenesis, embryogenesis, wound healing and organ development. Mechanical stress stimulates i.e. processes like growth, proliferation and remodeling of the surfaces.
To study the stress-strain relation in model tissues Madin-Darby canine kidney II cells were seeded on fibronectin coated polydimethylsiloxane elastomer chambers in a droplet wise manner. The resulting surface was uniaxially stretched with amplitudes of 0, 10, 20 and 30%. Subsequently the reaction and growth of clusters was imaged in phase contrast on timescales from minutes to days.
We present a comprehensive study of tissue growth after stretching. The change in cell size, elongation and orientation as well as connectivity and relaxation was investigated.