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BP: Fachverband Biologische Physik

BP 29: Posters - Multi-Cellular Systems

BP 29.8: Poster

Dienstag, 21. März 2017, 14:00–16:00, P2-EG

Cell Jamming: Connecting the Shape and Density Dependences — •Steffen Grosser, Linda Oswald, Jürgen Lippoldt, Paul Heine, and Josef A. Käs — Universität Leipzig, Germany

Cellular dynamics has been shown to display characteristics of jamming transitions which originally had been observed as a function of cell number density (Angelini et al., PNAS 2011). Recently, the Self-Propelled Voronoi (SPV) model has predicted a density-independent transition as a result of the counterplay of adhesion and contractile forces (Bi et al., Nat. Phys. 2015), visible in the dimensionless shape parameter.

We present experimental data for MCF-10A and MDA-MB-231 showing that shape and number density actually evolve in close concert; shape parameters decrease under increasing cell density. This feature, not predicted by the SPV model, happens in both the epithelial and mesenchymal cell lines, albeit with different consequences. Mesenchymal cells strongly delay their jamming transition even under high densities.