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BP: Fachverband Biologische Physik

BP 3: Mechanics and Dynamics of 3D Tissues - Joint Focus Session (BP/CPP/DY) organized by Peter Loskill

BP 3.8: Vortrag

Montag, 20. März 2017, 12:15–12:30, SCH A251

Jamming and liquidity in 3D cancer cell aggregates — Linda Oswald¹, •Steffen Grosser¹, Jürgen Lippoldt¹, Steve Pawlizak¹, Anatol Fritsch², and Josef Käs¹ — ¹University of Leipzig — ²MPI CBG Dresden

Traditionally, tissues are treated as simple liquids, which holds for example for embryonic tissue. However, recent experiments have shown that this picture is insufficient for other tissue types, suggesting possible transitions to solid-like behavior induced by cellular jamming. The coarse-grained self-propelled Voronoi (SPV) model predicts such a transition depending on cell shape which is thought to arise from an interplay of cell-cell adhesion and cortical tension. We observe non-liquid behavior in 3D breast cancer spheroids of varying metastatic potential and correlate single cell shapes, single cell dynamics and collective dynamic behavior of fusion and segregation experiments via the SPV model.