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BP: Fachverband Biologische Physik

BP 35: Posters - Physics of Parasites (Focus Session)

BP 35.1: Poster

Dienstag, 21. März 2017, 14:00–16:00, P2-OG1

Monitoring the blood-stage infection and hemozoin clearance in malaria rodent models by a novel malaria diagnostic device — •Maria Pukancsik¹, Agnes Orban¹, Petra Molnar¹, Adam Butykai¹, Maria Rebelo², Thomas Hanscheid², Ahmed S I Aly³, and Istvan Kezsmarki¹ — ¹Dept. of Physics, Budapest University of Technology and Economics and MTA-BME Lendület Magneto-optical Spectroscopy Research Group,1111 Budapest, HU — ²Instituto de Medicina Molecular, Faculdade de Medicina, Lisbon, PO — ³Tulane University, Dept. of Tropical Medicine, New Orleans, USA

The first prototype of a diagnostic device was developed as a sensitive platform for malaria diagnosis. The rotating-crystal magneto-optical diagnostic technique (RMOD) targets the natural biomarker hemozoin, which is a magnetic microcrystalline heme compound produced by all species of malaria parasites such as Plasmodium falciparum and Plasmodium vivax. The in vivo investigation of the RMOD device was performed using P. falciparum-like and P. vivax-like species of malaria parasites infecting mice (e.g. P. berghei, P. chabaudi, P. yoelii, P. vinckei) in collaboration with the Instituto de Medicina Molecular and with the Department of Tropical Medicine at Tulane University. The lethal and non-lethal rodent malaria parasites that model different human strains and characteristics of the human blood stage were used in order to monitor the onset of the blood stage infection and compare the sensitivity of the device depending on the rodent strains. The hemozoin clearance was also monitored in vivo during and following the drug treatment of infected mice.