Dresden 2017 – scientific programme

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BP: Fachverband Biologische Physik

BP 39: Optogenetics for the Cytoskeleton - Focus Session organized by Ulrich Schwarz

BP 39.3: Talk

Wednesday, March 22, 2017, 10:15–10:45, SCH A251

Optogenetic switches to control cellular actin dynamics — •Robert Grosse — University of Marburg

Actin dynamics is essential for cellular functions such as adhesion, motility and spatial organization. The Rho-GTPase effector proteins of the formin family are tightly regulated through autoinhibitory interactions. Formins are potent actin assembly factors that can nucleate and elongate linear actin filaments for multiple cellular functions including transcriptional control. Here we discuss tools and approaches to rapidly and reversibly modulate actin assembly by light by targeting Rho-GTPases, formins and beyond at the plasma membrane as well as in the somatic cell nucleus.