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BP: Fachverband Biologische Physik

BP 4: Systems Biology & Gene Expression and Signalling

BP 4.7: Vortrag

Montag, 20. März 2017, 16:45–17:00, ZEU 250

Cellular memory couples sporulation and spore revival — Alper Mutlu^1,2, Stephanie Trauth^1,2, Marika Ziesack², Jan-Philip Bergeest², Karl Rohr^2,3, Nils Becker^2,3, Thomas Höfer^2,3, and •Ilka Bischofs^1,2 — ¹MPI for Terrestrial Microbiology — ²University of Heidelberg — ³DKFZ Heidelberg

In bacteria, entry into and exit from dormancy are controlled by regulatory networks with little known overlap, indicating that the two processes operate independently from each other. Using B. subtilis as a model we developed an advanced time-lapse microscopy assay and a fluorescent marker that reports on a spore’s differentiation history to study the effect of variable sporulation timing on nutrient-induced spore revival. We find that spores exhibit long-term phenotypic memory of their differentiation history. Modeling and experiments with re-programmed cells suggest that this memory creates a quantity versus quality trade-off to generate fewer but more efficient spores. We therefore suggest that phenotypic memory contributes to the emergence of complex adaptive traits.