Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 4: Systems Biology & Gene Expression and Signalling
BP 4.8: Vortrag
Montag, 20. März 2017, 17:00–17:15, ZEU 250
Inflammatory diseases from the network perspective — •Piotr Nyczka1, Amke Caliebe2, Silke Szymczak2, Carolin Knecht2, Kristina Schlicht2, Michael Krawczak2, and Marc-Thorsten Hütt1 — 1Jacobs University Bremen, Germany — 2Christian Albrechts University of Kiel, Germany
We have studied gene expression patterns (provided to us by the study within the framework of the sysINFLAME systems medicine consortium) of human patients with inflammatory diseases with respect to the gene centric metabolic networks.
Despite the fact of dealing with very noisy data we were able to find clear evidence of prominent differences between inflammatory diseases from the perspective of these networks. This difference was clearly visible even on purely topological level and result was robust across two diffrent human metabolism models, and different parameter values.
This is definitely important result and could be a serious step forward in further understanding of inflammatory diseases, from the network perspective. We will also discuss results regarding protein network perspective and give some more details about human metabolism and methods we use.