Dresden 2017 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
BP: Fachverband Biologische Physik
BP 48: Membranes and Vesicles II
BP 48.11: Vortrag
Donnerstag, 23. März 2017, 12:45–13:00, HÜL 386
Adhesion ability of angiotensin II with model membranes — Julia Preu1, Louis Tiefenauer2, and •Thomas Gutberlet3 — 1Department of Molecular Membrane Biology, Max-Planck-Institute of Biophysics, Frankfurt, Germany — 2Laboratory of Biomolecular Research, Paul Scherrer Institut, Villigen PSI, Switzerland — 3Jülich Centre for Neutron Science at Heinz Maier-Leibnitz Zentrum, Forschungszentrum Jülich GmbH, Garching, Germany
The octa-peptide angiotensin II (Ang II, (H2N-Asp*Arg*Val*Tyr*Ile* His*Pro*Phe*COOH)) is one of the key player on blood pressure regulation in mammals. Predominantly binding to the Angiotensin type 1 and 2 receptors, the hormone is one of several peptide ligands binding to G protein coupled receptors (GPCR). The chemical nature of the amino acid sequence has an impact on the behavior in the proximity of membranes, demonstrated using different membrane model systems and biophysical methods. Applying electrochemical impedance spectroscopy and small angle x-ray scattering a detailed view on the adhesion of the peptide with model membrane surfaces was performed. The role of specific amino acids involved in the interaction with the phospholipid head group were investigated and, studying a truncated version of Ang II, Ang (1-7), the key role of the C-terminal phenylalanine was proven.