Dresden 2017 – scientific programme

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BP: Fachverband Biologische Physik

BP 49: Physics of the Genesis of Life - Focus Session organized by Moritz Kreysing and Dieter Braun

BP 49.11: Talk

Thursday, March 23, 2017, 12:30–12:45, SCH A251

Divergent prebiotic synthesis of ribonucleotides — •Matthew Powner — UCL, London, UK

RNA is a leading candidate for the original informational biopolymer of life, however a common prebiotic pathways to both purine and pyrimidine ribonucleotides remain elusive. We recently described a prebiotically plausible synthesis of pyrimidine ribonucleotides, but both purine and pyrimidine nucleotides must be synthesised together to access an information rich biopolymer. A divergent strategy to synthesise pyrimidine and 8-oxo-purine ribonucleotides from prebiotic precursors will demonstrate for the first time generational parity between 8-oxo-purine and pyrimidine heterocycles, allowing stepwise synthesis with regiospecific, stereoselective glycosidation and simultaneous phosphorylation with stereochemical inversion to furnish the β-ribo-stereochemistry found in the biological nucleic acids.