Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 5: Single Molecule Biophysics
BP 5.6: Vortrag
Montag, 20. März 2017, 16:30–16:45, HÜL 386
Controling the translocation of polymers through by selective nanopore modifications — •Adwait Datar1, Umberto Marini Bettolo Marconi2, Simone Melchionna3, and Maria Fyta1 — 1Institute for Computational Physics, University of Stuttgart, Germany — 2School of Sciences and Technologies, University of Camerino, 62032 Camerino Italy — 3ISC - CNR, Institute for Complex Systems, Consiglio Nazionale delle Ricerche, Università La Sapienza, P.le A. Moro 2, 00185 Rome, Italy
The focus of this work is the process of charged polymer translocation through nanometer-sized nanopores. These nanopores are placed in a salt solution and can electrophoretically thread charged molecules. Our aim is to control the polymer dynamics throughout the translocation process and optimize the translocation speed. In order to achieve this, we attempt to tune the specific polymer-nanopore interactions by changing the pore characteristics. Specifically, we investigate the influence of a variety of different patterns of the charge distribution within the nanopore on guiding the polymer dynamics. Our work is based on a multiscale computational approach seemlessly coupling the dynamics of the polymer with an electrokinetic description for the salt solution in which the translocation process takes place. Our results are evaluated with respect to different sensors characteristics in the nanopore, the flow patterns within the pore, and the velocity of the translocated polymer, as well as the cooperativity of solution, flow, and nanopore. We discuss the impact of our work in selectively engineering nanopores for single molecule experiments and DNA sequencing.