Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 5: Single Molecule Biophysics

BP 5.8: Vortrag

Montag, 20. März 2017, 17:00–17:15, HÜL 386

Analytical catch-slip bond model for arbitrary forces and loading rates — •Jakob Tómas Bullerjahn and Klaus Kroy — Universität Leipzig, Institut für Theoretische Physik, Leipzig, Germany

Some biological bonds exhibit a so-called catch regime, where the bond strengthens with increasing load. We build upon recent advances in slip-bond kinetics [1] to develop an analytically tractable, microscopic catch-slip bond model [2]. To facilitate the analysis of force-spectroscopy data, we calculate the bond’s mean lifetime and the rupture-force distribution for static loading and linear force ramps. Our results are applicable for arbitrary forces and loading rates, covering the whole range of conditions found in experiments and all-atom simulations. A generalization to account for force transducers of finite stiffness is also provided.

[1] J. T. Bullerjahn, S. Sturm & K. Kroy, Nat. Comm. 5, 4463 (2014). [2] J. T. Bullerjahn & K. Kroy, PRE 93, 012404 (2016).