Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 54: Statistical Physics of Biological Systems I (Joint Session BP/DY)
BP 54.8: Vortrag
Donnerstag, 23. März 2017, 16:45–17:00, ZEU 250
Incorporating sleep regulation and thalamocortical interactions in a cortical meanfield model — •Michael Schellenberger Costa1, Arne Weigenand1, Hong-Viet V. Ngo2, Lisa Marshall3, Jan Born2, Thomas Martinetz1, and Jens Christian Claussen4,1 — 1INB, U Lübeck — 2Med. Psych. and Behav. Neurobiol., U Tübingen — 3Neuroendocrinology, U Lübeck — 4Comp. Syst. Biol, Jacobs University Bremen
Few models accurately reproduce the complex rhythms of the thalamocortical system, as well as the dynamical patterns of sleep regulation. Here, we build upon previous work on a meanfield (neural mass) model of the sleeping cortex [1] and investigate the effect of neuromodulators on the dynamics of the cortex and the corresponding transition between wakefulness and the sleep stages [2]. We show that our simplified model generates essential features of human EEG over a full day. This approach builds a bridge between sleep regulatory models and EEG generating neural mass models. Based on model [1|, we also suggest a new interpretation of the mechanisms responsible for the generation of KCs and SOs [3]. A KC corresponds to a single excursion along the homoclinic orbit, while SOs are noise-driven oscillations around a stable focus. The model generates both time series and spectra that strikingly resemble real EEG data and points out differences between the stages of natural sleep.
[1] A. Weigenand et al., PloS Comp Biol (2014) [2] M. Schellenberger Costa et al., J. Comp. Neurosci. (2016) [3] M. Schellenberger Costa et al., PloS Comp Biol (2016)