Dresden 2017 – scientific programme

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BP: Fachverband Biologische Physik

BP 55: Cell Migration and Contraction

BP 55.2: Talk

Thursday, March 23, 2017, 15:30–15:45, HÜL 386

Collective cell migration on soft substrates — •Andriy Goychuk and Erwin Frey — Arnold Sommerfeld Center for Theoretical Physics, Ludwig-Maximilians-Universität, München, Deutschland

The extracellular matrix surrounding cells strongly influences their migratory behavior. This includes the decrease of cell proliferation with the substrate stiffness. To better understand this phenomenon, we study a modified Cellular Potts Model on a deformable hexagonal lattice. The cell polarization and cytoskeletal remodeling is simulated by a coarse-grained routine on a sub-cellular level. We show that cells exhibit a fast and persistent motion in the higher range of substrate stiffness, unlike in the lower range. In the intermediate regime, the cells show more complex behavior and move in groups.