Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 7: Posters - Mechanics and Dynamics of 3D Tissues (Focus Session)

BP 7.5: Poster

Montag, 20. März 2017, 17:30–19:30, P3

Time-dependent tension drives collective cell migration in zebrafish — •Bernhard Wallmeyer¹, Sarah Trinschek², Sargon Yigit¹, Uwe Thiele², and Timo Betz¹ — ¹Institute of Cell Biology, Center for Molecular Biology of Inflammation, Von-Esmarch-Str. 56, 48149 Münster, Germany — ²Institute for Theoretical Physics, University of Münster, 48149 Münster, Germany

Collective cell migration is a fundamental process during embryogenesis and adult life. An in vivo model for collective cell migration is epiboly. Epiboly is an event occurring in early zebrafish development, where the cells that initially form a cluster at one pole of the spherical yolk, spread towards the other pole in a continuous movement to eventually fully cover the yolk. Inspired by the physics of wetting we determine the contact angle between the cells and the yolk during epiboly. Similar to the situation of a liquid drop on a surface there are three interfaces, namely, between cells-medium, yolk-cells and yolk-medium that carry mechanical tension. By assuming that the origin of interface tension lies in cell-cell adhesion we propose a time-dependent tension due to the dynamics of adhesive contacts. Using the classical physics of wetting this model accurately characterizes the contact angle measured in our experiments. We are thus able to describe the fundamental and complex developmental mechanism of morphogenesis onset by three main parameters – the static tension strength α, the offset angle δ and the time scale λ.