Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 7: Posters - Mechanics and Dynamics of 3D Tissues (Focus Session)
BP 7.6: Poster
Montag, 20. März 2017, 17:30–19:30, P3
A new method for analyzing high-frequency microrheology data — •Kengo Nishi1, Maria Kilfoil2, Fred MacKintosh3, and Christoph Schmidt1 — 1Goettingen University, Goettingen, Germany — 2University of Massachusetts Amherst, Massachusetts, USA — 3Rice University, Houston, USA
Passive microrheology is an experimental technique used to measure the mechanical response of materials from the fluctuations of micron-sized beads embedded in the medium. In one common approach, one uses the fluctuation-dissipation theorem to obtain the imaginary part of the material response function from the power spectral density of bead displacement fluctuations, while the real part of the response function is calculated using a Kramers-Kronig integral. The high-frequency cut-off of this integral strongly affects the real part of the response function in the high frequency region. To moderate this high-frequency cut-off, we recently proposed a new analysis method for passive microrheology by using the fluctuation-dissipation theorem in time domain, i.e., Fourier transforming the time derivative of the mean squared displacement or the auto correlation function. To see the validity of this method, we conducted one- and two-particle microrheology experiments, and the systematic error analysis by synthetic data.