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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 15: Poster: Membranes, Biomaterials, Biopolymers

CPP 15.13: Poster

Montag, 20. März 2017, 18:30–21:00, P1C

The Dielectric Permittivity of Protein Solutions — •Susanne Liese and Roland R. Netz — Department of Physics, Free University Berlin, Arnimallee 14, 14195 Berlin, Germany

Electrostatic interactions are essential to understand the conformation and function of proteins. For a quantitative understanding of electrostatics of biological systems, for instance to describe the internal electric field of transmembrane proteins, the dielectric permittivity of proteins has to be known. We here present molecular dynamic simulations of protein solutions, which especially allow us to take the interaction of the protein and the hydration water into account. By studying the dielectric permittivity in dependence of the protein concentration, we can extrapolate our results to the limit of a pure protein and disentangle water and protein contributions to the electrostatic interaction.