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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 45: Biomaterials and Biopolymers (joint session BP/CPP, organized by BP)

CPP 45.1: Vortrag

Mittwoch, 22. März 2017, 15:00–15:15, SCH A251

The microstructural function of the tendon-bone insertion — •Leone Rossetti¹, Lara A. Kuntz^1,2, Elena Kunold³, Jonathan Schock¹, Kei W. Müller⁴, Heinrich Grabmayr¹, Josef Stolberg-Stolberg⁵, Franz Pfeiffer¹, Stephan A. Sieber³, Rainer Burgkart², and Andreas R. Bausch¹ — ¹Physik Department,TU München,D-85748 Garching, Germany — ²Klinik für Orthopaedie und Sportorthopaedie, Klinikum rechts der Isar, TU München, D-81675 München, Germany — ³CIPSM, Department of Chemistry, TU München, D-85747 Garching, Germany — ⁴Institute for Computational Mechanics , TU München, D-85748 Garching, Germany — ⁵University Hospital Münster, D-48149 Münster, Germany

The exceptional mechanical properties of the connection of tendon to bone rely on an intricate interplay of its biomolecular composition, microstructure and micromechanics. Here we identify that the Achilles tendon insertion is characterized by a stress reducing mechanism within an interfacial zone of 500 micrometres, with a distinct fiber organisation and biomolecular composition. Proteomic analysis detects enrichment in the interface region that are predominantly involved in cartilage and skeletal development as well as proteoglycan metabolism. Micromechanical testing coupled with multiscale confocal microscopy identifies a heterogenous mechanical response in the interface area, endowing the enthesis with a graded response to strains acting from different angles. The presented mechanisms mark a guideline for further biomimetic strategies to rationally design hard-soft interfaces.