Dresden 2017 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 45: Biomaterials and Biopolymers (joint session BP/CPP, organized by BP)
CPP 45.6: Vortrag
Mittwoch, 22. März 2017, 16:30–16:45, SCH A251
Model-independent measurements of ATP diffusion in PEG-DA hydrogels with various mesh sizes — •Günter Majer1 and Alexander Southan2 — 1MPI für Intelligente Systeme, Heisenbergstr. 3, 70569 Stuttgart, Germany — 2Institut für Grenzflächenverfahrenstechnik und Plasmatechnologie IGVP, Universität Stuttgart, Nobelstraße 12, 70569 Stuttgart, Germany
Hydrogels are semi-solid polymer networks formed by cross-linked hydrophilic polymer chains, with mesh sizes that can be tailored by varying the concentration and/or the molecular mass of the polymers. Well-defined hydrogels are ideal materials for various applications including drug delivery, transport of nutrients, or devices to separate small molecules chromatographically. In this context, a fundamental understanding of the diffusion processes of solutes in hydrogels with different mesh sizes is important. A powerful tool to determine the diffusion coefficients of solutes directly, i.e. without the need of a fluorescent label and independent of any diffusion-model assumptions, is pulsed field gradient nuclear magnetic resonance (PFG-NMR). In this work, polyethylene glycol diacrylate (PEG-DA)-based hydrogels with mesh sizes ranging from 1.35 to 3.70 nm were prepared using polymers with molecular masses between 700 and 8000 g/mol and concentrations of up to 30%. The diffusion coefficients of adenosine triphosphate (ATP) in these hydrogels were studied by PFG-NMR. The correlation between the mesh sizes and the diffusion coefficients is analyzed and discussed.