Dresden 2017 – scientific programme

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DY: Fachverband Dynamik und Statistische Physik

DY 2: Stochastic thermodynamics and information processing

DY 2.8: Talk

Monday, March 20, 2017, 11:45–12:00, HÜL 186

Thermodynamics of error correction — •Simone Pigolotti¹ and Pablo Sartori² — ¹Max-Planck Institute for the Physics of Complex Systems, Dresden, Germany — ²Rockefeller University, New York

Biological systems are able to replicate information with outstanding accuracy. In biochemical reactions, such as DNA duplication, different monomers can be distinguished because of their binding energies or via non-equilibrium kinetic mechanisms. I will show how, in simple copying reactions, these two discrimination modes are mutually exclusive and lead to opposite tradeoffs between error, dissipation and reaction velocity. In multi-step reactions, such as in kinetic proofreading, these different modes can be combined to improve overall accuracy. I will conclude by discussing how the second law of thermodynamics can be used to directly relate copying accuracy with thermodynamic observables.