Dresden 2017 – wissenschaftliches Programm

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MA: Fachverband Magnetismus

MA 35: Magnetic Particles / Clusters

MA 35.12: Vortrag

Mittwoch, 22. März 2017, 12:15–12:30, HSZ 101

Tuning applied field characteristics to improve efficiency of magnetic hyperthermia — •Oliver Laslett, Hans Fangohr, and Ondrej Hovorka — Faculty of Engineering and the Environment, University of Southampton, Southampton, SO17 1BJ, United Kingdom

The effectiveness of magnetic hyperthermia therapy depends not only upon the material properties of magnetic particles but also on their interaction with one another and their environment. The applied magnetic field is limited in both amplitude and frequency to ensure patient safety and comfort. We investigate the ability of novel waveform shapes to overcome this limit and improve treatment effectiveness. We present multiple theoretical and numerical approaches to simulating the induced power loss in heterogeneous ensembles of magnetic nanoparticles subjected to an arbitrary external field waveform. Crucially, we demonstrate the extent to which linear response theory and transition state theory accurately approximate full simulation of the Langevin dynamics. We also consider the filtering effect of hardware on high frequency switching fields. Subjecting magnetic nanoparticles to non-sinusoidal alternating fields affects the efficacy of treatment and the potential costs of material synthesis. We acknowledge financial support from the EPSRC grant EP/G03690X/1