Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 1: Protein Structure and Dynamics

BP 1.4: Vortrag

Montag, 12. März 2018, 10:30–10:45, H 1028

Stochastic modeling of multiprotein complex formation — •Stefanie Förste, Reinhard Lipowsky, and Sophia Rudorf — Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

The formation of a multiprotein complex, arising from the assembly of multiple peptide chains inside the crowded cell environment, is subject of ongoing research. In contrast to the canonical view that protein assembly is a post-translational process, recent experiments show that protein complexes can also assemble co-translationally, i.e., the different chains may assemble before translation has finished. Here, we investigate under which conditions post translational and/or co-translational assembly can occur. We analyze the influence of different parameters - such as the spatial distance of the translation sites - on the assembly dynamics using a combination of Gillespie simulations and analytical Markov modeling. In particular, we study the cross-over from a co-translational to a post-translational assembly regime.