Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Postersession II

BP 10.29: Poster

Montag, 12. März 2018, 17:30–19:30, Poster C

Cells Modeled as Osmotically Pressurized Elastic Shells — •Behzad Golshaei, Renata Garces, Samaneh Rezvani, and Christoph F Schmidt — Drittes Physikalisches Institut - Biophysik, Fakultät für Physik, Georg-August-Universität Göttingen

Animal cells, as well as bacteria, are mechanically protected by a viscoelastic envelope consisting of lipid membranes and polymer networks. External mechanical stimulation leads to responses such as deformations or flows. In order to understand the mechanical behavior of cells, we model cells as pressurized elastic shells using finite element modeling. We study how geometrical parameters (cortex thickness and cell diameter), thermodynamic effects (osmotic pressure difference), and material properties (Young*s modulus) affect the response of a cell to indentation. We focus on the time scales where cellular systems show elastic behavior in order to compare our model with experimental results. Results from two types of experimental set-ups have been used to parameterize linear elasticity equations. The first set of experiments used an optical trap to indent mammalian cells, and in the second set, bacteria were indented by beads of varying diameter using AFM.