Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 10: Postersession II
BP 10.39: Poster
Montag, 12. März 2018, 17:30–19:30, Poster C
Bacterial adhesion on nanostructured silicon surfaces — •Friederike Nolle1, Johannes Mischo1, Christian Spengler1, Nicolas Thewes1, Markus Bischoff2, and Karin Jacobs1 — 1Department of Experimental Physics, Saarland University, Saarbruecken — 2Institute for Medical Microbiology and Hygiene, Saarland University, Homburg/Saar
To prevent the inflammation of a medical implant, its material specifications are of crucial importance. An ideal surface would hinder bacterial biofilm formation and/or kill adhering pathogens without harming surrounding somatic cells. Surface modifications of single attributes have to be controlled and possible changes in adhesion of bacteria to these surfaces have to be observed. This study focuses on the nano-roughness of silicon surfaces, obtained by wet chemical etching, and its influence on bacterial adhesion (Staphylococcus aureus). The adhesion of bacteria is mediated by biopolymers, the properties of which we are able to characterize by AFM force spectroscopy, where the probe is a single bacterium. With our setup an insight into the adhesion force of Staphylococcus aureus was gained and also changes of the bacterial viability on the rough surfaces compared to smooth silicon surfaces were examined. In addition, the impact of hydrophobicity of rough silicon surfaces on adhesion was considered by silanizing the hydrophilic silicon.