Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Postersession II

BP 10.42: Poster

Montag, 12. März 2018, 17:30–19:30, Poster C

Tissue competition: The role of cross adhesion — •Tobias Büscher and Jens Elgeti — Theoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, D-52425 Jülich, Germany

Cells grow and divide, which implies a change in volume. In physical terms, the conjugate force to a change in volume is a pressure. Thus, in order to grow, cells must exert mechanical pressure on the neighbouring tissue. In turn, mechanical stress influences growth. Indeed, experiments on the growth of a cancer cell line display a reduction in proliferation due to mechanical pressure [1,2,3]. This effect leads to a mechanical contribution when tissues compete for space. The tissue with higher homeostatic pressure, i.e. the pressure at which cell division and death balance, overwhelms the weaker one [4,5]. We expand these works to include different adhesion properties. We find that the cross adhesion between the two tissues plays a crucial role in the dynamics of the competition. Besides one overwhelming the other, we observe a variety of states in which the two tissues coexist, ranging from spherical inclusions to a bi-continous structure. Interestingly, cancer cells typically express less adhesion proteins.

[1] Montel et al, 2011, PRL 107, 188102

[2] Delanrue et al, 2013, PRL110, 138103

[3] Podewitz et al, 2016, EPL 109, 58005

[4] Basan et al, 2011, Phys. Biol. 8, 026014

[5] Podewitz et al, 2016 New J. Physics 18, 083020