Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Postersession II

BP 10.46: Poster

Montag, 12. März 2018, 17:30–19:30, Poster C

Sorting of malaria-infected red blood cells based on adhesion in shear flow — •Anil Kumar Dasanna and Ulrich Schwarz — BioQuant & Institute of Theoretical Physics, Heidelberg University, Heidelberg

Malaria is an infectious disease caused by the unicellular parasite Plasmodium falciparum. Once inside the human body, the parasite hides from the immune system inside the red blood cells, where it multiplies over a period of 48 hours, before it ruptures the host cell and infects new red blood cells. Infected red blood cells can be cleared by the spleen based on their altered mechanics. In order to avoid this, the parasite induces an adhesive system on the surface of the red blood cells, which is built up progressively over the 48 hours of the intracellular stage. Recently white blood cells have been shown to be sorted out using ligand patterns arranged with a small inclination angle with the shear flow direction. Using adhesive dynamics simulations for round cells, we show that this method can be also extended to sort out different stages of malaria-infected red blood cells. We predict an optimal range for key parameters, such as inclination angle and shear rate. Round shapes are only appropriate for the late stage of the infection and in order to understand sorting in the earlier stages, we also have implemented a deformable red blood cell model.