Berlin 2018 – scientific programme

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BP: Fachverband Biologische Physik

BP 10: Postersession II

BP 10.56: Poster

Monday, March 12, 2018, 17:30–19:30, Poster C

Fluid and Jammed Behaviour in Cell Spheroids — •Steffen Grosser, Linda Oswald, Jürgen Lippoldt, and Josef A. Käs — Peter-Debye-Institut für Physik weicher Materie, Universität Leipzig

Cell Spheroids are many-particle "droplets" of soft matter with a constant volume fraction of one, which however can display fluid or "jammed"/glassy behaviour, as we can show with bulk rheology and single-cell tracking. Full three-dimensional digital segmentation of spheroids into single cell volumes reveal that for epithelial vs. cancerous spheroids (MCF-10A vs MDA-MB-436), this change in fluidity is reflected in the cell arrangements (cell shape). This could affect histopathology, where malignancy and dedifferentiation are detected via cell shape changes.