Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Postersession II

BP 10.61: Poster

Montag, 12. März 2018, 17:30–19:30, Poster C

Decision-Making across the Lifespan: Neurocognitive Models of Ageing and Dementia — •Gunther Klobe — Department of Clinical Neurosciences, University of Cambridge, UK

In the study of healthy ageing and neurodegenerative diseases, there are marked variations between individuals in terms of behaviour and decision-making. I examine these individual differences, using neurally inspired models of decision-making based on the accumulation of evidence for each possible response in simple perceptual reaction time tasks.

By analysing behavioural data using such models (Linear Ballistic Accumulator, Drift-Diffusion Model), one gains insight into individual differences that are not apparent from a simple comparison of mean reaction times and error rates because the latter approach ignores crucial information hidden in the cross-trial distribution of reaction times within a single subject.

My initial work examines the effects of ageing on decision-making processes using behavioural data from a large cross-sectional study, known as CamCAN (Cambridge Centre for Ageing and Neuroscience). In due course I will perform a similar analysis on data from clinical studies with dementia patients.

In both populations the decision-making model parameters can then be correlated with existing structural brain imaging data and thus become interpretable in terms of neural architecture and physiology, hopefully improving our understanding of the links between brain structure and task performance.