Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Postersession II

BP 10.8: Poster

Montag, 12. März 2018, 17:30–19:30, Poster C

Tug of War and Coordination in Bidirectional Transport by Molecular Motors — •Omar Munoz and Stefan Klumpp — Institut für Nichtlineare Dynamik, Universität Göttingen

Intracellular cargo transport is known to be bidirectional and mediated by molecular motors that bind to the cargoes and cytoskeletal filaments. Theoretical models for bidirectional transport include a tug-of-war between the motors and motor coordination through a mediator. Here, a tug-of-war model is extended to include motor activation and inactivation as a mechanism for biochemical coordination. Stochastic simulations provide an understanding of the dynamics of this system and of the effect of this additional coordination. The proposed coordination model is successful in describing the experimental observations of unexpectedly long unidirectional runs as well as memory of the direction after forced unbinding. These results and the recent experimental findings suggest that models of bidirectional transport should be cargo specific and combine features of both coordination and tug-of-war.