Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 11: Bioimaging and Biopspectroscopy I

BP 11.12: Vortrag

Dienstag, 13. März 2018, 12:45–13:00, H 1028

Synchronization-based Reconstruction of Cardiac Electrical Wave Dynamics from Mechanical Deformation using High-speed 4D Ultrasound — •Jan Christoph, Jan Lebert, Ulrich Parlitz, and Stefan Luther — Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany

Heart rhythm disorders such as ventricular or atrial fibrillation are determined by turbulent electrical vortex wave activity, which occupies the heart muscle and causes irregular contractions and inefficient beating of the heart. Both cardiologists and basic scientists are highly interested in obtaining visualizations of this highly dynamic and complex wave structure and its 3D spatio-temporal organization throughout the heart muscle, to be able to develop strategies for its efficient and reliable termination during ablation or defibrillation therapies. In recent work, we have shown that high-resolution 4D ultrasound can be used to image vortex-like mechanical structures in the fibrillating heart and that it is possible to reconstruct an electromechanical vortex filament structure that characterizes the spatio-temporal organization of ventricular fibrillation within the heart wall. Here, we show that in addition to imaging the mechanical activity, it is possible to reconstruct the electrical wave dynamics, which caused the deformations of the tissue, and which remains invisible in the imaging experiments, numerically. Using a synchronization-based approach, we demonstrate that even complex electrical vortex wave patterns, such as spiral waves or spiral wave chaos, can be reconstructed in elastic excitable media from the analysis of the deformation mechanics.