Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 11: Bioimaging and Biopspectroscopy I
BP 11.5: Vortrag
Dienstag, 13. März 2018, 10:45–11:00, H 1028
NV based modular sensor platform for intracellular environmental sensing — Jan Vavra1,4, Ivan Rehor2, •Torsten Rendler3, Mona Jani4, Jan Bednar6,7, Michael M. Baksh5, Andrea Zappe3, Joerg Wrachtrup3, M. G. Finn5, and Petr Cigler4 — 1Department of Chemistry, University of Oslo, Norway — 2Debye Institute for Nanomaterials Science, University of Utrecht, Netherlands — 33th Physical Institut, University of Stuttgart, Germany — 4Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Czech Republic — 5School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, United States — 6CNRS, University Grenoble Alpes, France — 7Fac Med 1, Charles University Prague, Czech Republic
Monitoring intracellular concentration of chemical moietis is important for biomedical applications. We utilize the so called nitrogen vacancy color center (NV) in nanodiamonds (NDs) as a sensor working under physiological conditions. NVs itself are photostable and allow to sense for example magnetic fields or temperature in their direct vicinity. NDs have been shown to be of low toxicity and therefore form the perfect host for intracellular sensing. To enable chemical sensing we developed a hybrid sensor platform. A polymer is crafted to the ND surface hosting Gd(III) complexes that alter the NV spin lattice relaxation time T1. By triggering the release of Gd(III) by a chemical species, the change in T1 can be used to measure for example pH. In the current work we concentrate on the development and description of a new sensor by coating fluorescent nanodiamonds with a supported lipid bilayer.